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  Indian J Med Microbiol
 

Figure 2: Weight Loss at 1 year with high-intensity lifestyle interventions or pharmacotherapy combined with low-to-moderate-intensity lifestyle counseling. Shown are the percentages of participants in randomized, controlled trials who had weight loss of at least 5% or at least 10% of their initial weight at 1 year after a high intensity lifestyle intervention or pharmacotherapy that typically was combined with low-to-moderate-lifestyle intervention Counseling (≤1 session per month). Percentages shown are cumulative; the percentage of participants who lost at least 5% of their initial weight includes the percentages who lost at least 10%. For example, 68% of participants in the look AHEAD study lost at least 5% of their initial weight, and 37% of these participants lost at least 10%. The lifestyle interventions trials (Look AHEAD,[3] the Diabetes Prevention Program trial,[17] and the trial reported by Teixeira et al.[3],[17]) were selected because they were judged to be of fair or good quality by the Guidelines (2013) for the Management of Overweight and Obesity in Adults[5] and because the trial data are reported as categorical weight losses. Additional categorical weight-loss from the Diabetes Prevention Program trial[17] were provided by the Diabetes Prevention Program Research Group. The median percentages of participants who had a weight loss of at least 5% or 10% with each of five medications approved for long-term weight management are from a meta-analysis by Khere et al.[3],[5],[17] Data on the percentages of participants with weight loss at 1 year of at least 15% of their initial weight were available for the look AHEAD study[3],[8] (16%), the Diabetes Prevention Program trial[17] (11%), liraglutide[19] (14%), phentermine–topiramate[20] (32%), and naltrexone–bupropion[21] (14%)

Figure 2: Weight Loss at 1 year with high-intensity lifestyle interventions or pharmacotherapy combined with low-to-moderate-intensity lifestyle counseling. Shown are the percentages of participants in randomized, controlled trials who had weight loss of at least 5% or at least 10% of their initial weight at 1 year after a high intensity lifestyle intervention or pharmacotherapy that typically was combined with low-to-moderate-lifestyle intervention Counseling (≤1 session per month). Percentages shown are cumulative; the percentage of participants who lost at least 5% of their initial weight includes the percentages who lost at least 10%. For example, 68% of participants in the look AHEAD study lost at least 5% of their initial weight, and 37% of these participants lost at least 10%. The lifestyle interventions trials (Look AHEAD,<sup>[3]</sup> the Diabetes Prevention Program trial,<sup>[17]</sup> and the trial reported by Teixeira <i>et al</i>.<sup>[3],[17]</sup>) were selected because they were judged to be of fair or good quality by the Guidelines (2013) for the Management of Overweight and Obesity in Adults<sup>[5]</sup> and because the trial data are reported as categorical weight losses. Additional categorical weight-loss from the Diabetes Prevention Program trial<sup>[17]</sup> were provided by the Diabetes Prevention Program Research Group. The median percentages of participants who had a weight loss of at least 5% or 10% with each of five medications approved for long-term weight management are from a meta-analysis by Khere <i>et al</i>.<sup>[3],[5],[17]</sup> Data on the percentages of participants with weight loss at 1 year of at least 15% of their initial weight were available for the look AHEAD study<sup>[3],[8]</sup> (16%), the Diabetes Prevention Program trial<sup>[17]</sup> (11%), liraglutide<sup>[19]</sup> (14%), phentermine–topiramate<sup>[20]</sup> (32%), and naltrexone–bupropion<sup>[21]</sup> (14%)