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ORIGINAL ARTICLE
Year : 2016  |  Volume : 3  |  Issue : 1  |  Page : 24-27

Aqueous extracts of Rosmarinus officinalis, Urtica diocia, and soybean exert different effects on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues


1 Turkish Ministry of Health, Public Health Institution, Ankara, Turkey
2 Department of Medical Biochemistry, Faculty of Medicine, Ankara University, Ankara, Turkey
3 Department of Surgical Oncology, Faculty of Medicine, Ankara University, Ankara, Turkey

Correspondence Address:
Zahide Esra Durak
Turkish Ministry of Health, Public Health Institution, Ankara
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2394-2010.177491

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Objective: This study aimed to investigate effects of aqueous extracts of Rosmarinus officinalis, Urtica diocia, and soybean on adenosine deaminase (ADA) activity in cancerous and noncancerous gastric and colon tissues since it is key enzyme participating in DNA turn-over. Materials and Methods: In method, cancerous and noncancerous human gastric and colon tissues removed by surgical operations were studied. In the samples, ADA activities were measured with and without plant extract incubated for 1 h. Results: As a result, it has been observed that rosemary extract inhibits ADA enzyme in cancerous (P = 0.031) and noncancerous gastric tissues (P = 0.048), but not in colon tissues, and Urtica extract inhibits the enzyme only in the cancerous gastric tissue (P = 0.039). On contrast, soybean extract activates ADA enzyme in colon tissues significantly (P = 0.012). Conclusion: Inhibition of ADA enzyme might play a part in the proposed anti-cancer properties of rosemary and U. diocia. However, the finding of ADA activation in colon tissues by soybean extract is a new one which needs further verification.


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